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Pharmacological properties
Mircera's drug belongs to the pharmacological group of medicines, the action of which is aimed at stimulating erythro- and leukopoiesis. This is a synthetic medication, which is a new generation of long-acting hematopoietin activators. The main active ingredient of the drug is methoxypolyethylene glycol-epoetin beta.
Mircera's medication has a stimulating effect on the process of hematopoiesis, during which erythrocytes are formed. The process of formation of erythrocytes occurs in the kidneys, so the action of the drug extends, first of all, to this organ. The drug effectively combats the signs of anemia in kidney disease, normalizing hemoglobin levels.
Composition and form of release of Mircera
Mircera medication is available in the form of a soluble liquid with a light yellow tint, which is injected intravenously or under the patient's skin by injection. Mircera contains the following components:
The medicine is sold in vials in the form of a 0.3 ml syringe. The package contains instructions, a needle for an injection and the solution itself with the medication.
Method and features of application of Mircera
Once in the patient's body, the medication has a long exposure period, so the frequency of injections should be no more than once a month. The drug is prescribed only by the attending physician after carrying out all the necessary examinations of the patient, collecting tests and establishing an accurate anamnesis. Injections should also be given only by the attending physician under specially selected conditions. The medication is sterile, no preservatives added. The medication, ready for injection, should have a yellowish tint or be transparent, without precipitation. Before the injection, the medication must be warmed to room temperature, if it was previously in the refrigerator. The drug with the solution retains its properties and can be used for a month at a temperature not exceeding 30 ° C. After a month, the drug cannot be used and must be disposed of. Each bottle can be used only once, after which the remaining funds are thrown away. Do not shake the tube before use. It is necessary to comply with all the rules and regulations for storing the medication specified in the current instructions for use. Mircera medication is used for injections into the vein and under the skin. If the drug is injected under the skin, then the injection must be done in the shoulder region, abdomen or thigh. When taking a course with medication, you need to monitor hemoglobin.
The duration of the course and the recommended dosage of Mircera are prescribed by the attending physician, taking into account the clinical picture of the disease and the individual characteristics of the patient. The decision to cancel the drug, as well as to adjust the dose, is also made by the attending physician, who monitors the patient's condition throughout the entire duration of therapy. If the injection was missed for any reason, then it must be delivered as soon as possible after the skip, and then follow the established schedule. You should not prescribe Mircera's medication to children under the age of 18, since there is no exact data on the effect of the drug's components on a growing and developing organism. Elderly people, patients with liver disease do not need dose adjustment or duration of treatment. Recommendations for using Mircera's medication:
The medication can be injected under the skin or into a vein. It is necessary to carefully choose the site of administration of the drug. It is possible to put injections with a solution of the medication in the shoulder region, the front of the abdomen, without affecting the umbilical region, or the femoral region. Avoid getting the needle into moles, scars, scars, irritation, hematomas, swelling. The injection site must be changed; you cannot put the injection twice in one place. Before the injection, the injection site is treated with a special disinfecting solution to prevent infection from entering through the puncture site. After the injection, the injection site is also treated and, if necessary, a patch is applied to the wound. Mircera can only be administered by medical personnel with proper qualifications and therapeutic experience.
Analogs of Mircera
Epoetinum beta and Methoxypolyaethylenglycolum-epoetinum beta are analogs of the Mircera drug in composition and pharmacological effects.
Erythropoietin (EPO) is a glycoprotein hormone cytokine, the main regulator of erythropoiesis, which stimulates the formation of red blood cells from late progenitor cells (it binds to erythropoietin-sensitive receptors, which are located mainly on erythroblasts, and promotes active proliferation of blast cells) and increases the release of reticulums. One of the most difficult to detect doping is erythropoietin doping.
Erythropoietin belongs to the group - peptide hormones. The expediency of its use lies in the fact that it can cause an increase in the number of red blood cells in the blood and increase the oxygen capacity of the blood. Accordingly, more oxygen can be delivered to tissues (especially muscle!), Which increases the efficiency of the body.
Mircera (methoxypolyethylene glycol-epoetin beta) - basically this substance is no different from the previous erythropoietins, with the exception of polyethylene glycol attached to the structure of the drug, which contributes to a longer half-life: Mircera is in the body 6 times longer than darbpoetin-alpha and 20 times longer than epoetin, which creates the possibility of long intervals between drug injections.
All EPO preparations are used according to the same scheme, dosages are 50-300 U per kg of weight. The result becomes noticeable after two weeks of use. Most experts are inclined to believe that the drug should not be used for more than six weeks.
Erythropoietin doping is actively used in cyclic sports with a predominant manifestation of endurance (running, swimming, cross-country skiing, speed skating, all types of rowing, cycling and others), when the same movement is repeated many times, a large amount of energy is consumed, and the work itself is carried out at a very high intensity.
